Fatties do better after heart attacks
Some doctors will admit to a little schadenfreude that health freakery does not confer cardiac invulnerability. There is nothing more depressing for the family doctor than trying to advise a slim, trim, lycra clad, non-smoking, gym-visiting middle-aged vegetarian, who has just has his first heart attack, on life style changes.
So much easier to help the flabby lounge lizard who is three stone overweight and has not taken exercise since TV remote controls were invented.
Now we hear that fatties who have heart attacks may have a better prognosis than the the health freaks. Various theories are suggested.
(The) differences in body chemistry caused by obesity might play a role. For instance, levels of blood platelets, which can affect clotting, are lower in obese patients, while levels of fat in the heart tissue, which might have a protective effect, are higher. Another theory is that the higher levels of endogenous cannabinoids in obese people might be key. There is a growing body of evidence to suggest that these chemicals have a protective effect during a heart attack. (BBC)Counter intuitive research findings like this are a constant source of pleasure. But I shall not be rushing to put all my post-heart attack patients on a diet of Mars Bars and McDonalds.
Why do fatties seem to do better? I am not sure I buy into any of the chemical theories advanced above.The truth is probably more mundane.
The life time risk of heart attack is predominantly a function of the hand of cards you are dealt at birth. The fatties may have been lower risk at birth, but have brought the disease prematurely upon themselves. The thinnies were probably always high risk and, had they not looked after themselves, would probably have had their heart attack even sooner. Given that they were high risk from the beginning, and already have excellent lifestyles, there is not much more they can do but keep their fingers crossed.
Labels: fatties, heart attacks, mars bars, mcdonalds, prevention
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Thought-provoking Junk Food Science on When does it stop becoming a paradox?
"We know that the body of evidence, as even acknowledged by an expert review conducted by the National Institutes of Health, shows that weight gain with age or stable weights even if fat, for both men and women has the lowest death rates; while dieting, weight loss or fluctuating weights (yo-yoing), significantly increases the risk of actual death, cardiovascular diseases, type 2 diabetes and cancers."
If I were to find myself offering such a convoluted attempt to explain away observations, I hope I'd go back and scrutinise my premises. Remember, your premises are probably based on earlier research, and most medical research is rubbish.
Can I have fries with that?
mongoose
Dearieme said...
If I were to find myself offering such a convoluted attempt to explain away observations, I hope I'd go back and scrutinise my premises. Remember, your premises are probably based on earlier research, and most medical research is rubbish.
Wednesday, June 20, 2007 11:51:00 AM
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Quite right too, dearieme!
But, well, there is a new research project out every day, often reported in hushed and respectful tones by the media, and a pinch of salt always helps. Preferably on the fries!
To be serious, the longer I am in medicine, the more I DO believe in the genetics of illness susceptibility. I am not really poo pooing healthy life styles, but is amazing how many people defy all the odds.
And there is that nice Mark Spitz with his high cholesterol advertising Carol Vorderman in the USA
John
Sometimes it's difficult for people to comprehend that no matter what you do, you're not immortal.
Remember, your premises are probably based on earlier research, and most medical research is rubbish.
Premises (and indeed other aspects of a research project) are almost bound to be influenced, anyway, by earlier research; after all, we aren't tabula rasa. Moreover, it's sensible to be aware of earlier research.
But perhaps you're talking mainly or even only about meta-analysis? I see nothing wrong with it, when it's conducted properly.
You say 'most medical research is rubbish'. Can you justify that?
Jayann, it's an expression I first heard from a chap who has spent most of his life teaching Chemistry at Cambridge. I then kept my eyes open for a few years and decided that he had hit on a great, if approximate, truth. Will swimming soon after a meal place you at risk? Invented. Onanism make you blind? Nah. Does passive smoking kill? Evidence thin. Does a salty diet kill you? Very thin. A fatty diet? Apparently not. Being a bit overweight? Certainly not. ALL sorts of asbestos? Nope. On and on the list of taboos rolls, each shakier than the previous one. The probable explanations are that (1) some doctors are so ambitious that they'll publish any old twaddle, and (2) the medical world is well provided with puritans who will delight in finding out what we are doing and telling us to stop.
John Crippen wrote
"I DO believe in the genetics of illness susceptibility."
But illness still has to occur through a biological mechanism, not through a divine finger pointing at you and zapping you with a lightning bolt.
I think John is being provocative again :)
"But illness still has to occur through a biological mechanism, not through a divine finger pointing at you and zapping you with a lightning bolt."
Genetics don't count as biological? Just becaue we don't understand the mechanism this week...
So if we don't understand the causative mechanisms involved, should we be making public health recommendations? Sounds more like experimentation.
“Married…..With Children” "Dead Men Don't Do Aerobics" (0402) September 10, 1989
Jim Jupiter, “The Healthiest Man in Chicago” is killed off when he adopts Peg’s lifestyle.
AL) [signs] Okay. Come on, family meeting. [they all go to the couch and sit] Now, Peg, I know you think you're responsible for killing Jim. And yet you have no guilt of squashing the life out of me, but, that's another meeting. Anyhow, what I'm saying is you didn't kill Jim. Good health killed Jim. See, he purified his body so completely, that when finally called upon to do so, he couldn't handle the grease, and sugar and toxic waste that we call food. He rendered himself extinct. See, healthy people are like dinosaurs. They're aren't fit to survive. Jim's body couldn't handle the burgers, bon bons, and Twinkie suckin's like real Americans. Y'see, we are the truly strong.
PEGGY) You really think so, Al?
AL) As filth is my witness, Peg. See that cockroach over there?
PEGGY) [pointing finger] That one?
AL) No, that one. Oh, any of them. Do you see them carrying off a can of Wheat Germ?
KELLY) Gurm, Dad.
AL) Thanks, Pumpkin. Anyway, Peg, let's follow the example of our friend the cockroach. They were before man, they'll be after man. You know why? They eat crap. And I say, if it's good enough for the cockroach, then it's good enough for my family.
PEGGY) Oh Al, you really do care.
AL) You bet I do. I don't know about you guys, but I'm hungry enough to block a colon. Grease burgers for everyone. On Dad. What do you say?
They all excitedly grab their jackets and charge out the door.
They walla about the food they'll eat, like "I'm gonna eat butter pats", "lard lard", etc.
They exit.
Supered over the empty living room the words:
"This show is dedicated to our brother, The Mighty Cockroach. Let him show us the way."
........arf
Thanks for reminding us of one of my personal heroes, Al "American Everyman" Bundy, arf.
Al is a great reminder of the inevitable gulf between where one thinks, aged 21, one will be at 45-50, and the reality.
Could it be that fatter people are prone to "minor" heart attacks, caused (at least in part) by obesity, but which don't have such serious consequences? I have no knowledge of the subject, so this is just a shot in the dark.
Maybe it's just down to the amount of booze they guzzle with their salty fries - a former colleague of mine (he was Finnish) used to say that the alcoholics that landed on his slab had the healthiest coronary arteries.
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