
Today’s dose of wibble comes from two eminent herbalists: Jenny Jones of the
Herb Society, and Jane Gray, president of the
National Institute of “Medical” (sic) Herbalists. They are in the news today because of an article in the
Drugs and Therapeutics Bulletin. (DTB) Few outside the medical profession have heard of the DTB, which is a shame, as it is an excellent source of genuinely unbiased information about drugs.
DTB's aim is to provide informed and unbiased information on medical conditions, medicines and other treatments to enable people to make informed choices. True to this objective, DTB has always been wholly independent of the pharmaceutical industry, Government and regulatory authorities. DTB is also free of advertising and other forms of commercial sponsorship. All contributors are asked to declare whether they have any interests or relationships they think might influence their comments. These potential conflicts are taken into account during the editorial process. In addition, the extensive peer-review process exposes potential conflicts of interest. All comments must be supported by appropriate evidence.
Drugs and Therapeutics Bulletin
The DTB has been looking at the role of herbs in the treatment of menopausal symptoms. Straightaway we enter the lunatic world in which
“natural” is equated with
“good” and
“drug” is equated with
“evil”. If you want to make your doctor’s heart sink, ask him whether what he is prescribing is ‘natural’. My stock response to this is, “You mean, ‘natural’ like cowdung?”. To which the patient normally says, “Oh doctor, you are a tease, you know what I mean, is it a “drug”?

No, I don't know what you mean. Of course it is a drug. A drug is any substance which, when taken, has an effect on the body.
Drugs have good effects and bad effects. Which are good effects and which are bad effects depends on what you are trying to achieve. Beta blockers,
inter alia, slow the heart rate. Digoxin also (usually) slows the heart rate. Slowing the heart rate can be good or bad, depending on what therapeutic effect you want. Ventolin (salbutamol) opens up the tubes in the lungs. It may also reduce uterine contractions, which can be helpful if a woman is threatening to go into premature labour, but not so helpful if she is two weeks past her due date.
Drugs may be naturally occurring or they may be man-made. Often, they are naturally occurring but have been purified, qualified and quantified by man. Or, the naturally occurring drug may be synthesised in the laboratory.

If you are in atrial fibrillation, you can boil up a foxglove soup and gently sip it if you wish, or you can take a precise dose of digoxin as prescribed by your doctor.

The fact that a drug occurs naturally says nothing about its safety. Bella donna is a naturally occurring plant, better known as Deadly Nightshade.

Deadly Nightshade is both natural and potentially lethal. Any yet, it’s active ingredient, atropine, when purified and used in appropriate (and small) doses, is a very useful drug.
There is a certain sort of Guardian reading, tree-hugging woman who is insistent on having treatment for her menopause, but also equally insistent that the treatment should be “natural”. Do not mention
Premarin to her. She will tuck into goose liver pate, fillet steak, white veal and battery farmed chicken eggs, but will not hear of collecting the urine from pregnant mares. She is lacking in oestrogen, but does not want the doctor to give her oestrogen, either horse or man made. No, she wants Black Cohosh. “It’s natural, doctor”.
Trouble is, there is no evidence that Black Cohosh works. (There will be a flood of comments saying “It worked for me”. Yawn.) The DTB has been looking at herbal treatments for the menopause. In particular, it has studied:
Black Cohosh
Red Clover
Dong Quai
Evening Primrose
Ginseng
Wild Yam
Chase Tree
Kava Kava
The full article is essential reading if you are interested in the menopause, but you will have to pay to do so if you are not a subscriber. Mind you, it’s worth taking out a subscription to the DTB if you are genuinely interested in drugs. As always, the DTB approaches the subject with an open mind. Its main conclusion is that there not enough data to make a definitive judgment on the efficacy of herbal treatment of menopausal symptoms, but the data that does exist is not encouraging. There is however already enough data to raise serious concerns about side effects.
Side effects of herbal treatment
- Evidence suggests a possible association between black cohosh and liver toxicity,33,34 and the MHRA's Commission on Human Medicines has advised that it is important to inform users of black cohosh about this.
- Kava kava (Piper methysticum), which was previously widely used for anxiety, including that associated with the menopause, has been banned in the UK because of reports of liver damage with the herb.
- Ginseng appears to be well tolerated, but has been associated with unwanted effects such as headache, sleep problems and gastrointestinal disorders.16 Interactions have been reported between ginseng and warfarin (leading to a reduced INR), but the data are inconclusive and there may be differences between species. (On the other hand, gingko is thought to potentiate the action of anticoagulants.)
DTB
But don’t expect a lack of evidence about efficacy and worries about side effects to deter the herbalist wibble merchants.
Jenny Jones of the Herb Society said:
"A lack of evidence does not necessarily mean a lack of effect. Not much clinical research has been done and we do need more. But there is not the funding to do this type of work.”
Reasonable enough. But then Jenny puts the pencils up her nose and starts to wibble.
"As a practitioner I can tell you these remedies do work for some women."
BBC
Enter
Jane Gray, the President of the National Institute of “Medical” Herbalists, pencils already
in situJane Gray, president of the National Institute of Medical Herbalists, said: "In general, herbal preparations are extremely safe and possible side effects are generally mild - especially when compared to the possible side effects from a conventional treatment like HRT."
BBC
Jane Gray’s statement is rubbish. Many naturally herbs, such as Deadly Nightshade, are potentially lethal. As already stated by the DTB and, indeed, by Jenny Jones before she put her pencils in, there is not enough evidence to make a definitive judgment. And the liver toxicity that caused Kava Kava to be banned is hardly “mild”.
The National Institute of “Medical” Herbalists (NIMH) is fraudulently mis-named. The layman might assume that, as they are “medical”, that they are doctors. They are no more doctors than is “Dr” Gillian McKeith. As they are not doctors they skate on thin ice when they purport to be qualified to treat medical conditions.
Nick Panay is a well known gynaecologist with a specialist interest in the menopause. He approaches herbal treatment with an open mind. To a doctor, having an open mind means looking at the evidence. He has been looking at the evidence about red clover, and says:
"Some women will find herbal remedies beneficial. We have been studying red clover isoflavones and have found they have a small benefit above placebo. But just because these are alternative treatments it doesn't mean they are entirely safe. Any treatment can carry side effects."
Dr Nick Panay
If the herbalists were reputable and scientific, you would expect them to give wide publicity to the DTB and also to the work done by Dr Nick Panay. Sadly, that is not how they work. To the herbalist, when science comes in at the door, common sense goes out of the window.

Herbalist is asked to read the Drugs and Therapeutics BulletinNIMH has done its own “scientific” trial on the herbal treatment of menopausal symptoms. It is only two pages long, and can be found
here. Their study shows that herbal treatment produced a
"notable improvement in symptoms." Sadly, the methods used to run their trial were so unscientific that no one could take the results seriously. And that is the problem with all these wibble merchants. They will not do scientific trials and they ignore the results of the scientific trials that others do.
If you decide you want to have treatment for your menopausal symptoms, I would stick with the oestrogen.
Labels: "natural", drugs, fraud, herbalists, menopause, wibble